Modulation of IgE Synthesis by IgE-Binding Factors Released by T Cells of Asthmatic Patients with Elevated Serum IgE

Serum IgE in Asthmatic Children

Wood, C. B. S., and Oliver, J. (1972). Archives of Disease in Childhood, 47, 890. Serum IgE in asthmatic children: relation to age, sex, eczema, and skin sensitivity tests. A simple method was used to detect raised serum concentrations of IgE immunoglobulin in 237 asthmatic children. The lower limit of sensitivity of the method was 900 units/ml. 49% of the children were found to have concentrat...

Evaluation of the sensitization of asthmatic patients to A.alternata, P.citrinum and A.fumigatus by IgE-immunoblotting

Background: There is evidence to demonstrate an association between fungal sensitization and asthma. Several studies have shown that saprophytic fungi such as Alternaria, Penicillium and Aspergillus species are the most prevalent fungal allergens worldwide. The main purpose of this study was to compare Alternaria alternata, Penicillium ci...

Suppression of IgE B Cells and IgE Binding to Fc RI by Gene Therapy with Single-Chain Anti-IgE

IgE synthesis by chronic lymphocytic leukemia cells

The present results indicate that B cells isolated from chronic lymphocytic leukemia (B-CLL) from 11 of 14 patients are capable of specifically producing IgE upon costimulation with IL-4 and hydrocortisone (HC). IgE is detected by intracytoplasmic fluorescence staining and by RIA. Clinical, hematological, and immunological parameters (including Rai stage, WBC, Lc, sIg kappa/lambda, CD5, and CD2...

Inhibition of IgE and IgE/anti-IgE mediated responses in mast cells by Omalizumab

Results Omalizumab (10 ug/mL) inhibited IgE binding to LAD2 cells by 78% (P=0.007) compared to untreated control. Omalizumab (10 ug/mL) further blocked IgE-dependent upregulation of FcεRI expression by 90% (P=0.03). In addition, omalizumab removed FcεRI-bound IgE in a time-dependent manner; an effect that was detected as early as 24 hrs (57% removal; P<0.001) after addition of omalizumab result...